Publications

2020

Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception.

Neubarth NL, Emanuel AJ, Liu Y, Springel MW, Handler A, Zhang Q, Lehnert BP, Guo C, Orefice LL, Abdelaziz A, DeLisle MM, Iskols M, Rhyins J, Kim SJ, Cattel SJ, Regehr W, Harvey CD, Drugowitsch J, Ginty DD.

Science. 2020 Jun 19;368(6497):eabb2751. doi: 10.1126/science.abb2751. PMID: 32554568.

 

The emergence of transcriptional identity in somatosensory neurons.
Sharma N, Flaherty K, Lezgiyeva K, Wagner DE, Klein AM, Ginty DD.

Nature. 2020 Jan;577(7790):392-398. doi: 10.1038/s41586-019-1900-1. Epub 2020 Jan 8.PMID: 31915380

2019

Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models.
Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD.

Cell. 2019 Aug 8;178(4):867-886.e24. doi: 10.1016/j.cell.2019.07.024.PMID: 31398341

Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties.
Zheng Y, Liu P, Bai L, Trimmer JS, Bean BP, Ginty DD.

Neuron. 2019 Aug 21;103(4):598-616.e7. doi: 10.1016/j.neuron.2019.05.039. Epub 2019 Jun 24.PMID: 31248728
 

Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia.

Boyle KA, Gradwell MA, Yasaka T, Dickie AC, Polgár E, Ganley RP, Orr DPH, Watanabe M, Abraira VE, Kuehn ED, Zimmerman AL, Ginty DD, Callister RJ, Graham BA, Hughes DI.

Cell Rep. 2019 Jul 9;28(2):526-540.e6. doi: 10.1016/j.celrep.2019.06.040. PMID: 31291586; PMCID: PMC6635381.

 

Publisher Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis

Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. 

Nature. 2019 Jun;570(7760):E32. doi: 10.1038/s41586-019-1267-3. Erratum for: Nature. 2019 May;569(7755):229-235. PMID: 31114060.


Tiling and somatotopic alignment of mammalian low-threshold mechanoreceptors.
Kuehn ED, Meltzer S, Abraira VE, Ho CY, Ginty DD.
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9168-9177. doi: 10.1073/pnas.1901378116. Epub 2019 Apr 17.

Multiplexed peroxidase-based electron microscopy labeling enables simultaneous visualization of multiple cell types.
Zhang Q, Lee WA, Paul DL, Ginty DD.
Nat Neurosci. 2019 May;22(5):828-839. doi: 10.1038/s41593-019-0358-7. Epub 2019 Mar 18.

Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior.
Zimmerman AL, Kovatsis EM, Pozsgai RY, Tasnim A, Zhang Q, Ginty DD.
Neuron. 2019 Apr 17;102(2):420-434.e8. doi: 10.1016/j.neuron.2019.02.002. Epub 2019 Feb 27.

 

2018

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling.
Ye M, Lehigh KM, Ginty DD.
Elife. 2018 Jan 30;7. pii: e33012. doi: 10.7554/eLife.33012.

 

2017

Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons

Wang Q, Chiu SL, Koropouli E, Hong I, Mitchell S, Easwaran TP, Hamilton NR, Gustina AS, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. 

Neuron. 2017 Dec 6;96(5):1084-1098.e7. doi: 10.1016/j.neuron.2017.10.029. Epub 2017 Nov 16. PMID: 29154130; PMCID: PMC5726806.

Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses.

Browne LE, Latremoliere A, Lehnert BP, Grantham A, Ward C, Alexandre C, Costigan M, Michoud F, Roberson DP, Ginty DD, Woolf CJ.Cell Rep. 2017 Jul 5;20(1):89-98. doi: 10.1016/j.celrep.2017.06.024.PMID: 28683326 

Active Touch and Self-Motion Encoding by Merkel Cell-Associated Afferents.

Severson KS, Xu D, Van de Loo M, Bai L, Ginty DD, O'Connor DH.Neuron. 2017 May 3;94(3):666-676.e9. doi: 10.1016/j.neuron.2017.03.045. Epub 2017 Apr 20.PMID: 28434802 

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis.

Andreone BJ, Chow BW, Tata A, Lacoste B, Ben-Zvi A, Bullock K, Deik AA, Ginty DD, Clish CB, Gu C.Neuron. 2017 May 3;94(3):581-594.e5. doi: 10.1016/j.neuron.2017.03.043. Epub 2017 Apr 13.PMID: 28416077 

Retrogradely Transported TrkA Endosomes Signal Locally within Dendrites to Maintain Sympathetic Neuron Synapses.
Lehigh KM, West KM, Ginty DD.
Cell Rep. 2017 Apr 4;19(1):86-100. doi: 10.1016/j.celrep.2017.03.028.

The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O'Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD.
Cell. 2017 Jan 12;168(1-2):295-310.e19. doi: 10.1016/j.cell.2016.12.010.

 

2016

Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs.
Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD.
Cell. 2016 Jul 14;166(2):299-313. doi: 10.1016/j.cell.2016.05.033.

 

2015

Genetic Identification of an Expansive Mechanoreceptor Sensitive to Skin Stroking.
Bai L, Lehnert BP, Liu J, Neubarth NL, Dickendesher TL, Nwe PH, Cassidy C, Woodbury CJ, Ginty DD.
Cell. 2015 Dec 17;163(7):1783-95. doi: 10.1016/j.cell.2015.11.060

​Extrinsic and intrinsic signals converge on the Runx1/CBFβ transcription factor for nonpeptidergic nociceptor maturation.
Huang S, O'Donovan KJ, Turner EE, Zhong J, Ginty DD.
Elife. 2015 Sep 29;4:e10874. doi: 10.7554/eLife.1087

 

2014

The Cellular and Molecular Basis of Direction Selectivity of Aδ-LTMRs.
Rutlin M, Ho CY, Abraira VE, Cassidy C, Woodbury CJ, Ginty DD.
Cell. 2014 Dec 18;159(7):1640-51. doi: 10.1016/j.cell.2014.11.038.

The gentle touch receptors of mammalian skin.
Zimmerman A, Bai L, Ginty DD.
Science. 2014 Nov 21;346(6212):950-4. doi: 10.1126/science.1254229. Review.

Linx mediates interaxonal interactions and formation of the internal capsule
Mandai K, Reimert DV, Ginty DD.
Neuron. 2014 Jul 2;83(1):93-103. doi: 10.1016/j.neuron.2014.05.020. Epub 2014 Jun 12

The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles
Li, L., and Ginty, D.D. 
eLife, 2014 Feb 25;3:e01901. doi: 10.7554/eLife.01901.

 

2013

MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons.
Engelhard C, Sarsfield S, Merte J, Wang Q, Li P, Beppu H, Kolodkin AL, Sucov HM, Ginty DD.
Elife. 2013 Sep 17;2:e01160. doi: 10.7554/eLife.01160.

The sensory neurons of touch.
Abraira VE, Ginty DD.
Neuron. 2013 Aug 21;79(4):618-39. doi: 10.1016/j.neuron.2013.07.051. Review.

Long-distance retrograde neurotrophic factor signalling in neurons.
Harrington AW, Ginty DD.
Nat Rev Neurosci. 2013 Mar;14(3):177-87. doi: 10.1038/nrn3253. Review.

 

2012

Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland.
Liu Y, Rutlin M, Huang S, Barrick CA, Wang F, Jones KR, Tessarollo L, Ginty DD
Science. 2012 Dec 7;338(6112):1357-60. doi: 10.1126/science.1228258.

Dystroglycan organizes axon guidance cue localization and axonal pathfinding.
Wright KM, Lyon KA, Leung H, Leahy DJ, Ma L, Ginty DD.
Neuron. 2012 Dec 6;76(5):931-44. doi: 10.1016/j.neuron.2012.10.009.

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.
de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH.
Nat Neurosci. 2012 Jun 10;15(7):1022-31. doi: 10.1038/nn.3141

 

2011

The functional organization of cutaneous low-threshold mechanosensory neurons.
Li L, Rutlin M, Abraira VE, Cassidy C, Kus L, Gong S, Jankowski MP, Luo W, Heintz N, Koerber HR, Woodbury CJ, Ginty DD.
Cell. 2011 Dec 23;147(7):1615-27. doi: 10.1016/j.cell.2011.11.027.

Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival.
Harrington AW, St Hillaire C, Zweifel LS, Glebova NO, Philippidou P, Halegoua S, Ginty DD
Cell. 2011 Aug 5;146(3):421-34. doi: 10.1016/j.cell.2011.07.008

 

2010

An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates.
Guo T, Mandai K, Condie BG, Wickramasinghe SR, Capecchi MR,Ginty DD.
Nat Neurosci. 2011 Jan;14(1):31-6. doi: 10.1038/nn.2710. Epub 2010 Dec 12.

Long-distance control of synapse assembly by target-derived NGF.
Sharma N, Deppmann CD, Harrington AW, St Hillaire C, Chen ZY, Lee FS, Ginty DD.
Neuron. 2010 Aug 12;67(3):422-34. doi: 10.1016/j.neuron.2010.07.018

SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells.
Smith-Hicks C, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF, Linden DJ.
Nat Neurosci. 2010 Sep;13(9):1082-9. doi: 10.1038/nn.2611. Epub 2010 Aug 8

A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal.
Merte J, Wang Q, Vander Kooi CW, Sarsfield S, Leahy DJ, Kolodkin AL, Ginty DD.
J Neurosci. 2010 Apr 21;30(16):5767-75. doi: 10.1523/JNEUROSCI.5061-09.2010

 

2009

Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling.
Luo W, Enomoto H, Rice FL, Milbrandt J, Ginty DD.
Neuron. 2009 Dec 24;64(6):841-56. doi: 10.1016/j.neuron.2009.11.003

Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS.
Tran TS, Rubio ME, Clem RL, Johnson D, Case L, Tessier-Lavigne M, Huganir RL, Ginty DD, Kolodkin AL.
Nature. 2009 Dec 24;462(7276):1065-9. doi: 10.1038/nature08628. Epub 2009 Dec 13

Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.
Merte J, Jensen D, Wright K, Sarsfield S, Wang Y, Schekman R, Ginty DD.
Nat Cell Biol. 2010 Jan;12(1):41-6; sup pp 1-8. doi: 10.1038/ncb2002. Epub 2009 Dec 6

Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.
Kolk SM, Gunput RA, Tran TS, van den Heuvel DM, Prasad AA, Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JP, Smidt MP, Pasterkamp RJ.
J Neurosci. 2009 Oct 7;29(40):12542-57. doi: 10.1523/JNEUROSCI.2521-09.2009

LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.
Mandai K, Guo T, St Hillaire C, Meabon JS, Kanning KC, Bothwell M, Ginty DD.
Neuron. 2009 Sep 10;63(5):614-27. doi: 10.1016/j.neuron.2009.07.031

 

2008

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development.
Newbern J, Zhong J, Wickramasinghe RS, Li X, Wu Y, Samuels I, Cherosky N, Karlo JC, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman YQ, Charron J, Ginty DD, Watanabe M, Saitta SC, Snider WD, Landreth GE.
Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17115-20. doi: 10.1073/pnas.0805239105. Epub 2008 Oct 24

The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value.
Johnson AW, Chen X, Crombag HS, Zhang C, Smith DR, Shokat KM, Gallagher M, Holland PC, Ginty DD.
Eur J Neurosci. 2008 Sep;28(5):997-1002. doi: 10.1111/j.1460-9568.2008.06383.x. Epub 2008 Jul 26

Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons.
Wickramasinghe SR, Alvania RS, Ramanan N, Wood JN, Mandai K, Ginty DD.
Neuron. 2008 May 22;58(4):532-45. doi: 10.1016/j.neuron.2008.03.006

Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons.
Makita T, Sucov HM, Gariepy CE, Yanagisawa M, Ginty DD.
Nature. 2008 Apr 10;452(7188):759-63. doi: 10.1038/nature06859

A model for neuronal competition during development.
Deppmann CD, Mihalas S, Sharma N, Lonze BE, Niebur E, Ginty DD.
Science. 2008 Apr 18;320(5874):369-73. doi: 10.1126/science.1152677. Epub 2008 Mar 6

 

2007

A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons.
Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty DD.
Neuron. 2007 Jun 7;54(5):739-54

 

2006

Retrograde control of neural circuit formation.
Deppmann CD, Ginty DD.
Cell. 2006 Dec 29;127(7):1306-7

Calcium signals control Wnt-dependent dendrite growth.
Alvania RS, Chen X, Ginty DD.
Neuron. 2006 Jun 15;50(6):813-5. Review.

A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons.
Riccio A, Alvania RS, Lonze BE, Ramanan N, Kim T, Huang Y, Dawson TM, Snyder SH, Ginty DD.
Mol Cell. 2006 Jan 20;21(2):283-94

 

2005

Distinct roles for secreted semaphorin signaling in spinal motor axon guidance.
Huber AB, Kania A, Tran TS, Gu C, De Marco Garcia N, Lieberam I, Johnson D, Jessell TM, Ginty DD, Kolodkin AL.
Neuron. 2005 Dec 22;48(6):949-64

Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival.
Lee J, Kim CH, Simon DK, Aminova LR, Andreyev AY, Kushnareva YE, Murphy AN, Lonze BE, Kim KS, Ginty DD, Ferrante RJ, Ryu H, Ratan RR.
J Biol Chem. 2005 Dec 9;280(49):40398-401. Epub 2005 Oct 5

Functions and mechanisms of retrograde neurotrophin signalling.
Zweifel LS, Kuruvilla R, Ginty DD.
Nat Rev Neurosci. 2005 Aug;6(8):615-25. Review

Growth and survival signals controlling sympathetic nervous system development.
Glebova NO, Ginty DD.
Annu Rev Neurosci. 2005;28:191-222. Review

Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors.
Valdez G, Akmentin W, Philippidou P, Kuruvilla R, Ginty DD, Halegoua S.
J Neurosci. 2005 May 25;25(21):5236-47

SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability.
Ramanan N, Shen Y, Sarsfield S, Lemberger T, Schütz G, Linden DJ, Ginty DD.
Nat Neurosci. 2005 Jun;8(6):759-67. Epub 2005 May 8

A chemical-genetic approach to studying neurotrophin signaling.
Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD.
Neuron. 2005 Apr 7;46(1):13-21

Secreted semaphorins modulate synaptic transmission in the adult hippocampus.
Sahay A, Kim CH, Sepkuty JP, Cho E, Huganir RL, Ginty DD, Kolodkin AL.
J Neurosci. 2005 Apr 6;25(14):3613-20

 

2004

Restricted inactivation of serum response factor to the cardiovascular system.
Miano JM, Ramanan N, Georger MA, de Mesy Bentley KL, Emerson RL, Balza RO Jr, Xiao Q, Weiler H, Ginty DD, Misra RP.
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17132-7. Epub 2004 Nov 29

Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins.
Chen AE, Ginty DD, Fan CM.
Nature. 2005 Jan 20;433(7023):317-22. Epub 2004 Nov 28

Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins.
Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD.
Science. 2005 Jan 14;307(5707):265-8. Epub 2004 Nov 18

Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve.
Schwarz Q, Gu C, Fujisawa H, Sabelko K, Gertsenstein M, Nagy A, Taniguchi M, Kolodkin AL, Ginty DD, Shima DT, Ruhrberg C.
Genes Dev. 2004 Nov 15;18(22):2822-34

Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections.
Cloutier JF, Sahay A, Chang EC, Tessier-Lavigne M, Dulac C, Kolodkin AL, Ginty DD.
J Neurosci. 2004 Oct 13;24(41):9087-96

A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling.
Kuruvilla R, Zweifel LS, Glebova NO, Lonze BE, Valdez G, Ye H,Ginty DD.
Cell. 2004 Jul 23;118(2):243-55

Heterogeneous requirement of NGF for sympathetic target innervation in vivo.
Glebova NO, Ginty DD.
J Neurosci. 2004 Jan 21;24(3):743-51

 

2003

Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events.
Sahay A, Molliver ME, Ginty DD, Kolodkin AL.
J Neurosci. 2003 Jul 30;23(17):6671-8

Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development.
Gu C, Rodriguez ER, Reimert DV, Shu T, Fritzsch B, Richards LJ, Kolodkin AL, Ginty DD.
Dev Cell. 2003 Jul;5(1):45-57

Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons.
Ye H, Kuruvilla R, Zweifel LS, Ginty DD.
Neuron. 2003 Jul 3;39(1):57-68

Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Annu Rev Neurosci. 2003;26:509-63. Epub 2003 Mar 28. Review

 

2002

Function and regulation of CREB family transcription factors in the nervous system.
Lonze BE, Ginty DD.
Neuron. 2002 Aug 15;35(4):605-23. Review

Retrograde neurotrophin signaling: Trk-ing along the axon.
Ginty DD, Segal RA.
Curr Opin Neurobiol. 2002 Jun;12(3):268-74. Review

Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB.
Lonze BE, Riccio A, Cohen S, Ginty DD.
Neuron. 2002 Apr 25;34(3):371-85

CREB family transcription factors inhibit neuronal suicide.
Dawson TM, Ginty DD.
Nat Med. 2002 May;8(5):450-1

What a privilege to reside at the synapse: NMDA receptor signaling to CREB.
Riccio A, Ginty DD.
Nat Neurosci. 2002 May;5(5):389-90

Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons.
Cloutier JF, Giger RJ, Koentges G, Dulac C, Kolodkin AL, Ginty DD.
Neuron. 2002 Mar 14;33(6):877-92

Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165.
Gu C, Limberg BJ, Whitaker GB, Perman B, Leahy DJ, Rosenbaum JS, Ginty DD, Kolodkin AL.
J Biol Chem. 2002 May 17;277(20):18069-76. Epub 2002 Mar 8

 

2001

SH2-B and APS are multimeric adapters that augment TrkA signaling.
Qian X, Ginty DD.
Mol Cell Biol. 2001 Mar;21(5):1613-20

 

2000

Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons.
Kuruvilla R, Ye H, Ginty DD.
Neuron. 2000 Sep;27(3):499-512

Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism.
Sasaki M, Gonzalez-Zulueta M, Huang H, Herring WJ, Ahn S,Ginty DD, Dawson VL, Dawson TM.
Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8617-22

Spatial considerations for stimulus-dependent transcription in neurons.
Ahn S, Riccio A, Ginty DD.
Annu Rev Physiol. 2000;62:803-23. Review

Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins.
Giger RJ, Cloutier JF, Sahay A, Prinjha RK, Levengood DV, Moore SE, Pickering S, Simmons D, Rastan S, Walsh FS, Kolodkin AL, Ginty DD, Geppert M.
Neuron. 2000 Jan;25(1):29-41

 

1999

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons.
Riccio A, Ahn S, Davenport CM, Blendy JA, Ginty DD.
Science. 1999 Dec 17;286(5448):2358-61

Characterization of an NGF-P-TrkA retrograde-signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons.
Tsui-Pierchala BA, Ginty DD.
J Neurosci. 1999 Oct 1;19(19):8207-18

A late phase of cerebellar long-term depression requires activation of CaMKIV and CREB.
Ahn S, Ginty DD, Linden DJ.
Neuron. 1999 Jul;23(3):559-68

 

1998

Patterning of cortical efferent projections by semaphorin-neuropilin interactions.
Polleux F, Giger RJ, Ginty DD, Kolodkin AL, Ghosh A.
Science. 1998 Dec 4;282(5395):1904-6

Effects of PS1 deficiency on membrane protein trafficking in neurons.
Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS.
Neuron. 1998 Nov;21(5):1213-21

Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity.
Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL.
Neuron. 1998 Nov;21(5):1079-92

Identification and characterization of novel substrates of Trk receptors in developing neurons.
Qian X, Riccio A, Zhang Y, Ginty DD.
Neuron. 1998 Nov;21(5):1017-29

A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos.
Ahn S, Olive M, Aggarwal S, Krylov D, Ginty DD, Vinson C.
Mol Cell Biol. 1998 Feb;18(2):967-77

 

1997

Steering clear of semaphorins: neuropilins sound the retreat.
Kolodkin AL, Ginty DD.
Neuron. 1997 Dec;19(6):1159-62. Review.

Neuropilin is a semaphorin III receptor.
Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD.
Cell. 1997 Aug 22;90(4):753-62

An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons.
Riccio A, Pierchala BA, Ciarallo CL, Ginty DD.
Science. 1997 Aug 22;277(5329):1097-100

Calcium regulation of gene expression: isn't that spatial?
Ginty DD.
Neuron. 1997 Feb;18(2):183-6. Review

 

1996

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.
Xing J, Ginty DD, Greenberg ME.
Science. 1996 Aug 16;273(5277):959-63

Light entrainment and activation of signal transduction pathways in the SCN.
Kornhauser JM, Ginty DD, Greenberg ME, Mayo KE, Takahashi JS.
Prog Brain Res. 1996;111:133-46. Review

 

1995

Induction of a nerve growth factor-sensitive kinase that phosphorylates the DNA-binding domain of the orphan nuclear receptor NGFI-B.
Hirata Y, Whalin M, Ginty DD, Xing J, Greenberg ME, Milbrandt J, Guroff G.
J Neurochem. 1995 Oct;65(4):1780-8

Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase.
Miranti CK, Ginty DD, Huang G, Chatila T, Greenberg ME.
Mol Cell Biol. 1995 Jul;15(7):3672-84

Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals.
Bonni A, Ginty DD, Dudek H, Greenberg ME.
Mol Cell Neurosci. 1995 Apr;6(2):168-83

L-type voltage-sensitive Ca2+ channel activation regulates c-fos transcription at multiple levels.
Thompson MA, Ginty DD, Bonni A, Greenberg ME.
J Biol Chem. 1995 Mar 3;270(9):4224-35

Calcium regulation of gene expression.
Rosen LB, Ginty DD, Greenberg ME.
Adv Second Messenger Phosphoprotein Res. 1995;30:225-53. Review

 

1994

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.
Ginty DD, Bonni A, Greenberg ME.
Cell. 1994 Jun 3;77(5):713-25

Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras.
Rosen LB, Ginty DD, Weber MJ, Greenberg ME.
Neuron. 1994 Jun;12(6):1207-21

Calcium regulation of gene expression in neuronal cells.
Ghosh A, Ginty DD, Bading H, Greenberg ME.
J Neurobiol. 1994 Mar;25(3):294-303. Review

 

1993

A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.
Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME.
Mol Cell Biol. 1993 Oct;13(10):6260-73

Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.
Ginty DD, Kornhauser JM, Thompson MA, Bading H, Mayo KE, Takahashi JS, Greenberg ME.
Science. 1993 Apr 9;260(5105):238-4

Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.
Bading H, Ginty DD, Greenberg ME.
Science. 1993 Apr 9;260(5105):181-6

 

1992

Trans-synaptic regulation of gene expression.
Ginty DD, Bading H, Greenberg ME.
Curr Opin Neurobiol. 1992 Jun;2(3):312-6. Review

The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells.
Ginty DD, Fanger GR, Wagner JA, Maue RA.
J Cell Biol. 1992 Mar;116(6):1465-73

Synergistic effects of nerve growth factor and phorbol 12-myristate 13-acetate on rapid motility and process formation in PC12 cells: the role of laminin.
Glowacka D, Ginty DD, Wagner JA.
J Neurosci Res. 1992 Feb;31(2):263-72

 

1991

Induction of immediate early genes by Ca2+ influx requires cAMP-dependent protein kinase in PC12 cells.
Ginty DD, Glowacka D, Bader DS, Hidaka H, Wagner JA.
J Biol Chem. 1991 Sep 15;266(26):17454-8

Nerve growth factor-induced neuronal differentiation after dominant repression of both type I and type II cAMP-dependent protein kinase activities.
Ginty DD, Glowacka D, DeFranco C, Wagner JA.
J Biol Chem. 1991 Aug 15;266(23):15325-33

Retinoic acid stimulates the differentiation of PC12 cells that are deficient in cAMP-dependent protein kinase.
Scheibe RJ, Ginty DD, Wagner JA.
J Cell Biol. 1991 Jun;113(5):1173-82

 

1990

Multiple pathways for the regulation of ornithine decarboxylase in intestinal epithelial cells.
Ginty DD, Marlowe M, Pekala PH, Seidel ER.
Am J Physiol. 1990 Mar;258(3 Pt 1):G454-60

Apparent post-transcriptional modification of ornithine decarboxylase accounts for its induction in IEC-6 cells in culture.
Seidel ER, Ginty DD.
Digestion. 1990;46 Suppl 2:383-9

 

1989

Putrescine stimulates DNA synthesis in intestinal epithelial cells.
Ginty DD, Osborne DL, Seidel ER.
Am J Physiol. 1989 Jul;257(1 Pt 1):G145-50

Polyamine-dependent growth and calmodulin-regulated induction of ornithine decarboxylase.
Ginty DD, Seidel ER.
Am J Physiol. 1989 Feb;256(2 Pt 1):G342-8

 

1987

Neurogenic pulmonary edema in a pulmonary normotensive model.
Beckman DL, Ginty DD, Gaither AC.
Proc Soc Exp Biol Med. 1987 Nov;186(2):170-3

A pyrene fluorescence technique and microchamber for measurement of oxygen consumption of single isolated axons.
Hargittai PT, Ginty DD, Lieberman EM.
Anal Biochem. 1987 Jun;163(2):418-26

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