Publications
2024
Sensory Input, Sex, and Function Shape Hypothalamic Cell Type Development.
Kaplan HS, Logeman BL, Zhang K, Santiago C, Sohail N, Naumenko S, Ho Sui SJ, Ginty DD, Ren B, Dulac C. bioRxiv [Preprint]. 2024 Jan 23:2024.01.23.576835. doi: 10.1101/2024.01.23.576835. PMID: 38328205.
Nerve injury disrupts temporal processing in the spinal cord dorsal horn through alterations in PV+ interneurons.
Rankin G, Chirila AM, Emanuel AJ, Zhang Z, Woolf CJ, Drugowitsch J, Ginty DD. Cell Rep. 2024 Jan 30;43(2):113718. doi: 10.1016/j.celrep.2024.113718. Epub ahead of print. PMID: 38294904.
The developmental timing of spinal touch processing alterations predicts behavioral changes in genetic mouse models of autism spectrum disorders.
Tasnim A, Alkislar I, Hakim R, Turecek J, Abdelaziz A, Orefice LL, Ginty DD. Nat Neurosci. 2024 Jan 17. doi: 10.1038/s41593-023-01552-9. Epub ahead of print. PMID: 38233682.
2023
Activity-dependent development of the body's touch receptors.
Santiago C, Sharma N, Africawala N, Siegrist J, Handler A, Tasnim A, Anjum R, Turecek J, Lehnert BP, Renauld S, Nolan-Tamariz M, Iskols M, Magee AR, Paradis S, Ginty DD. bioRxiv. 2023 Sep 25:2023.09.23.559109. doi: 10.1101/2023.09.23.559109. Preprint. PMID: 37790437
Coding of self and environment by Pacinian neurons in freely moving animals.
Turecek J, Ginty DD. bioRxiv. 2023 Sep 13:2023.09.11.557225. doi: 10.1101/2023.09.11.557225. Preprint. PMID: 37745531
Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch.
Handler A, Zhang Q, Pang S, Nguyen TM, Iskols M, Nolan-Tamariz M, Cattel S, Plumb R, Sanchez B, Ashjian K, Shotland A, Brown B, Kabeer M, Turecek J, DeLisle MM, Rankin G, Xiang W, Pavarino EC, Africawala N, Santiago C, Lee WA, Xu CS, Ginty DD. Neuron. 2023 Sep 13::S0896-6273(23)00634-7. doi: 10.1016/j.neuron.2023.08.023. Online ahead of print. PMID: 37725982
Skin-type-dependent development of murine mechanosensory neurons.
Koutsioumpa C, Santiago C, Jacobs K, Lehnert BP, Barrera V, Hutchinson JN, Schmelyun D, Lehoczky JA, Paul DL, Ginty DD. Dev Cell. 2023 Aug 14:S1534-5807(23)00367-2. doi: 10.1016/j.devcel.2023.07.020. Epub ahead of print. PMID: 37607547
The projection-specific signals that establish functionally segregated dopaminergic synapses.
Terauchi A, Yee P, Johnson-Venkatesh EM, Seiglie MP, Kim L, Pitino JC, Kritzer E, Zhang Q, Zhou J, Li Y, Ginty DD, Lee WA, Umemori H. Cell. 2023 Aug 9:S0092-8674(23)00801-2. doi: 10.1016/j.cell.2023.07.023. Online ahead of print. PMID: 37591240
DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.
Wolfson RL, Abdelaziz A, Rankin G, Kushner S, Qi L, Mazor O, Choi S, Sharma N, Ginty DD. Cell. 2023 Aug 3;186(16):3368-3385.e18. doi: 10.1016/j.cell.2023.07.007. PMID: 37541195
Calretinin-expressing islet cells: a source of pre- and post-synaptic inhibition of non-peptidergic nociceptor input to the mouse spinal cord.
Davis OC, Dickie AC, Mustapa MB, Boyle KA, Browne TJ, Gradwell MA, Smith KM, Polgár E, Bell AM, Kókai É, Watanabe M, Wildner H, Zeilhofer HU, Ginty DD, Callister RJ, Graham BA, Todd AJ, Hughes DI. Sci Rep. 2023 Jul 18;13(1):11561. doi: 10.1038/s41598-023-38605-9. PMID: 37464016
Krause corpuscles of the genitalia are vibrotactile sensors required for normal sexual behavior.
Qi L, Iskols M, Handler A, Ginty DD. bioRxiv. 2023 Jun 15:2023.06.14.545006. doi: 10.1101/2023.06.14.545006. Preprint. PMID: 37398085
A Hypothalamic Circuit Underlying the Dynamic Control of Social Homeostasis.
Liu D, Rahman M, Johnson A, Tsutsui-Kimura I, Pena N, Talay M, Logeman BL, Finkbeiner S, Choi S, Capo-Battaglia A, Abdus-Saboor I, Ginty DD, Uchida N, Watabe-Uchida M, Dulac C. bioRxiv. 2023 May 19:2023.05.19.540391. doi: 10.1101/2023.05.19.540391. Preprint. PMID: 37293031
Tasnim A, Alkislar I, Hakim R, Turecek J, Abdelaziz A, Orefice LL, Ginty DD. bioRxiv. 2023 May 9:2023.05.09.539589. doi: 10.1101/2023.05.09.539589. Preprint. PMID: 37214862
A DRG genetic toolkit reveals molecular, morphological, and functional diversity of somatosensory neuron subtypes.
Qi L, Iskols M, Shi D, Reddy P, Walker C, Lezgiyeva K, Voisin T, Pawlak M, Kuchroo VK, Chiu I, Ginty DD, Sharma N. bioRxiv. 2023 Apr 23:2023.04.22.537932. doi: 10.1101/2023.04.22.537932. Preprint. PMID: 37131664
γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons.
Meltzer S, Boulanger KC, Chirila AM, Osei-Asante E, DeLisle M, Zhang Q, Kalish BT, Tasnim A, Huey EL, Fuller LC, Flaherty EK, Maniatis T, Garrett AM, Weiner JA, Ginty DD. Neuron. 2023 Jun 7;111(11):1776-1794.e10. doi: 10.1016/j.neuron.2023.03.012. Epub 2023 Apr 6. PMID: 37028432
Koropouli E, Wang Q, Mejías R, Hand R, Wang T, Ginty DD, Kolodkin AL. eLife. 2023 Apr 3;12:e83217. doi: 10.7554/eLife.83217. PMID: 37010951
Handler A, Zhang Q, Pang S, Nguyen TM, Iskols M, Nolan-Tamariz M, Cattel S, Plumb R, Sanchez B, Ashjian K, Shotland A, Brown B, Kabeer M, Turecek J, Rankin G, Xiang W, Pavarino EC, Africawala N, Santiago C, Lee WA, Shan Xu C, Ginty DD. bioRxiv. 2023 Mar 18:2023.03.17.533188. doi: 10.1101/2023.03.17.533188. Preprint. PMID: 36993253
Rankin G, Chirila AM, Emanuel AJ, Zhang Z, Woolf CJ, Drugowitsch J, Ginty DD. bioRxiv. 2023 Mar 21:2023.03.20.533541. doi: 10.1101/2023.03.20.533541. Preprint. PMID: 36993199
2022
The encoding of touch by somatotopically aligned dorsal column subdivisions.
Turecek J, Lehnert BP, Ginty DD. Nature. 2022 Dec;612(7939):310-315. doi: 10.1038/s41586-022-05470-x. Epub 2022 Nov 23. PMID: 36418401
Chirila AM, Rankin G, Tseng SY, Emanuel AJ, Chavez-Martinez CL, Zhang D, Harvey CD, Ginty DD. Cell. 2022 Nov 23;185(24):4541-4559.e23. doi: 10.1016/j.cell.2022.10.012. Epub 2022 Nov 4. PMID: 36334588
Meltzer S, Boulanger KC, Osei-Asante E, Handler A, Zhang Q, Sano C, Itohara S, Ginty DD. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2210421119. doi: 10.1073/pnas.2210421119. Epub 2022 Oct 17. PMID: 36252008
2021
Cortical responses to touch reflect subcortical integration of LTMR signals.
Emanuel AJ, Lehnert BP, Panzeri S, Harvey CD, Ginty DD. Nature. 2021 Dec;600(7890):680-685. doi: 10.1038/s41586-021-04094-x. Epub 2021 Nov 17. PMID: 34789880
Mechanoreceptor synapses in the brainstem shape the central representation of touch.
Lehnert BP, Santiago C, Huey EL, Emanuel AJ, Renauld S, Africawala N, Alkislar I, Zheng Y, Bai L, Koutsioumpa C, Hong JT, Magee AR, Harvey CD, Ginty DD. Cell. 2021 Oct 28;184(22):5608-5621.e18. doi: 10.1016/j.cell.2021.09.023. Epub 2021 Oct 11. PMID: 34637701
The cellular and molecular basis of somatosensory neuron development.
Meltzer S, Santiago C, Sharma N, Ginty DD. Neuron. 2021 Dec 1;109(23):3736-3757. doi: 10.1016/j.neuron.2021.09.004. Epub 2021 Sep 29. PMID: 34592169
The mechanosensory neurons of touch and their mechanisms of activation.
Handler A, Ginty DD. Nat Rev Neurosci. 2021 Sep;22(9):521-537. doi: 10.1038/s41583-021-00489-x. Epub 2021 Jul 26. PMID: 34312536
Jeon SM, Chang D, Geske A, Ginty DD, Caterina MJ. J Neurosci. 2021 Jun 30;41(26):5595-5619. doi: 10.1523/JNEUROSCI.1668-20.2021. Epub 2021 May 24. PMID: 34031166
Santiago IJ, Zhang D, Saras A, Pontillo N, Xu C, Chen X, Weirauch MT, Mistry M, Ginty DD, Pecot MY, Peng J. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2025530118. doi: 10.1073/pnas.2025530118. PMID: 33766917
2020
Parallel ascending spinal pathways for affective touch and pain.
Choi S, Hachisuka J, Brett MA, Magee AR, Omori Y, Iqbal NU, Zhang D, DeLisle MM, Wolfson RL, Bai L, Santiago C, Gong S, Goulding M, Heintz N, Koerber HR, Ross SE, Ginty DD. Nature. 2020 Oct 28. doi: 10.1038/s41586-020-2860-1. PMID: 33116307
Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception.
Neubarth NL, Emanuel AJ, Liu Y, Springel MW, Handler A, Zhang Q, Lehnert BP, Guo C, Orefice LL, Abdelaziz A, DeLisle MM, Iskols M, Rhyins J, Kim SJ, Cattel SJ, Regehr W, Harvey CD, Drugowitsch J, Ginty DD. Science. 2020 Jun 19;368(6497):eabb2751. doi: 10.1126/science.abb2751. PMID: 32554568.
The emergence of transcriptional identity in somatosensory neurons.
Sharma N, Flaherty K, Lezgiyeva K, Wagner DE, Klein AM, Ginty DD. Nature. 2020 Jan;577(7790):392-398. doi: 10.1038/s41586-019-1900-1. Epub 2020 Jan 8. PMID: 31915380
2019
Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models.
Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD. Cell. 2019 Aug 8;178(4):867-886.e24. doi: 10.1016/j.cell.2019.07.024. PMID: 31398341
Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties.
Zheng Y, Liu P, Bai L, Trimmer JS, Bean BP, Ginty DD. Neuron. 2019 Aug 21;103(4):598-616.e7. doi: 10.1016/j.neuron.2019.05.039. Epub 2019 Jun 24. PMID: 31248728
Boyle KA, Gradwell MA, Yasaka T, Dickie AC, Polgár E, Ganley RP, Orr DPH, Watanabe M, Abraira VE, Kuehn ED, Zimmerman AL, Ginty DD, Callister RJ, Graham BA, Hughes DI. Cell Rep. 2019 Jul 9;28(2):526-540.e6. doi: 10.1016/j.celrep.2019.06.040. PMID: 31291586
Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis
Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Nature. 2019 Jun;570(7760):E32. doi: 10.1038/s41586-019-1267-3. Erratum for: Nature. 2019 May;569(7755):229-235. PMID: 31114060
Tiling and somatotopic alignment of mammalian low-threshold mechanoreceptors.
Kuehn ED, Meltzer S, Abraira VE, Ho CY, Ginty DD. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9168-9177. doi: 10.1073/pnas.1901378116. Epub 2019 Apr 17. PMID: 30996124
Multiplexed peroxidase-based electron microscopy labeling enables simultaneous visualization of multiple cell types.
Zhang Q, Lee WA, Paul DL, Ginty DD. Nat Neurosci. 2019 May;22(5):828-839. doi: 10.1038/s41593-019-0358-7. Epub 2019 Mar 18. PMID: 30886406
Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior.
Zimmerman AL, Kovatsis EM, Pozsgai RY, Tasnim A, Zhang Q, Ginty DD. Neuron. 2019 Apr 17;102(2):420-434.e8. doi: 10.1016/j.neuron.2019.02.002. Epub 2019 Feb 27. PMID: 30826183
2018
Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling.
Ye M, Lehigh KM, Ginty DD. eLife. 2018 Jan 30;7. pii: e33012. doi: 10.7554/eLife.33012. PMID: 29381137
2017
Wang Q, Chiu SL, Koropouli E, Hong I, Mitchell S, Easwaran TP, Hamilton NR, Gustina AS, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. Neuron. 2017 Dec 6;96(5):1084-1098.e7. doi: 10.1016/j.neuron.2017.10.029. Epub 2017 Nov 16. PMID: 29154130
Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses.
Browne LE, Latremoliere A, Lehnert BP, Grantham A, Ward C, Alexandre C, Costigan M, Michoud F, Roberson DP, Ginty DD, Woolf CJ. Cell Rep. 2017 Jul 5;20(1):89-98. doi: 10.1016/j.celrep.2017.06.024. PMID: 28683326
Active Touch and Self-Motion Encoding by Merkel Cell-Associated Afferents.
Severson KS, Xu D, Van de Loo M, Bai L, Ginty DD, O'Connor DH. Neuron. 2017 May 3;94(3):666-676.e9. doi: 10.1016/j.neuron.2017.03.045. Epub 2017 Apr 20. PMID: 28434802
Andreone BJ, Chow BW, Tata A, Lacoste B, Ben-Zvi A, Bullock K, Deik AA, Ginty DD, Clish CB, Gu C. Neuron. 2017 May 3;94(3):581-594.e5. doi: 10.1016/j.neuron.2017.03.043. Epub 2017 Apr 13. PMID: 28416077
Retrogradely Transported TrkA Endosomes Signal Locally within Dendrites to Maintain Sympathetic Neuron Synapses.
Lehigh KM, West KM, Ginty DD. Cell Rep. 2017 Apr 4;19(1):86-100. doi: 10.1016/j.celrep.2017.03.028. PMID: 28380365
The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O'Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD. Cell. 2017 Jan 12;168(1-2):295-310.e19. doi: 10.1016/j.cell.2016.12.010. PMID: 28041852
2016
Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs.
Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD. Cell. 2016 Jul 14;166(2):299-313. doi: 10.1016/j.cell.2016.05.033. PMID: 27293187
2015
Genetic Identification of an Expansive Mechanoreceptor Sensitive to Skin Stroking.
Bai L, Lehnert BP, Liu J, Neubarth NL, Dickendesher TL, Nwe PH, Cassidy C, Woodbury CJ, Ginty DD. Cell. 2015 Dec 17;163(7):1783-95. doi: 10.1016/j.cell.2015.11.060. PMID: 26687362
Extrinsic and intrinsic signals converge on the Runx1/CBFβ transcription factor for nonpeptidergic nociceptor maturation.
Huang S, O'Donovan KJ, Turner EE, Zhong J, Ginty DD. eLife. 2015 Sep 29;4:e10874. doi: 10.7554/eLife.1087. PMID: 26418744
2014
The Cellular and Molecular Basis of Direction Selectivity of Aδ-LTMRs.
Rutlin M, Ho CY, Abraira VE, Cassidy C, Woodbury CJ, Ginty DD. Cell. 2014 Dec 18;159(7):1640-51. doi: 10.1016/j.cell.2014.11.038. PMID: 29698636
The gentle touch receptors of mammalian skin.
Zimmerman A, Bai L, Ginty DD. Science. 2014 Nov 21;346(6212):950-4. doi: 10.1126/science.1254229. Review. PMID: 25414303
Linx mediates interaxonal interactions and formation of the internal capsule
Mandai K, Reimert DV, Ginty DD. Neuron. 2014 Jul 2;83(1):93-103. doi: 10.1016/j.neuron.2014.05.020. Epub 2014 Jun 12. PMID: 24930700
The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles
Li, L., and Ginty, D.D. eLife, 2014 Feb 25;3:e01901. doi: 10.7554/eLife.01901. PMID: 24569481
2013
MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons.
Engelhard C, Sarsfield S, Merte J, Wang Q, Li P, Beppu H, Kolodkin AL, Sucov HM, Ginty DD. eLife. 2013 Sep 17;2:e01160. doi: 10.7554/eLife.01160. PMID: 24052814
The sensory neurons of touch.
Abraira VE, Ginty DD. Neuron. 2013 Aug 21;79(4):618-39. doi: 10.1016/j.neuron.2013.07.051. Review. PMID: 23972592
Long-distance retrograde neurotrophic factor signalling in neurons.
Harrington AW, Ginty DD. Nat Rev Neurosci. 2013 Mar;14(3):177-87. doi: 10.1038/nrn3253. Review. PMID: 23422909
2012
Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland.
Liu Y, Rutlin M, Huang S, Barrick CA, Wang F, Jones KR, Tessarollo L, Ginty DD. Science. 2012 Dec 7;338(6112):1357-60. doi: 10.1126/science.1228258. PMID: 23224557
Dystroglycan organizes axon guidance cue localization and axonal pathfinding.
Wright KM, Lyon KA, Leung H, Leahy DJ, Ma L, Ginty DD. Neuron. 2012 Dec 6;76(5):931-44. doi: 10.1016/j.neuron.2012.10.009. PMID: 23217742
Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.
de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH. Nat Neurosci. 2012 Jun 10;15(7):1022-31. doi: 10.1038/nn.3141. PMID: 22683681
2011
The functional organization of cutaneous low-threshold mechanosensory neurons.
Li L, Rutlin M, Abraira VE, Cassidy C, Kus L, Gong S, Jankowski MP, Luo W, Heintz N, Koerber HR, Woodbury CJ, Ginty DD. Cell. 2011 Dec 23;147(7):1615-27. doi: 10.1016/j.cell.2011.11.027. PMID: 22196735
Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival.
Harrington AW, St Hillaire C, Zweifel LS, Glebova NO, Philippidou P, Halegoua S, Ginty DD. Cell. 2011 Aug 5;146(3):421-34. doi: 10.1016/j.cell.2011.07.008. PMID: 21816277
2010
An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates.
Guo T, Mandai K, Condie BG, Wickramasinghe SR, Capecchi MR,Ginty DD. Nat Neurosci. 2011 Jan;14(1):31-6. doi: 10.1038/nn.2710. Epub 2010 Dec 12. PMID: 21151121
Long-distance control of synapse assembly by target-derived NGF.
Sharma N, Deppmann CD, Harrington AW, St Hillaire C, Chen ZY, Lee FS, Ginty DD. Neuron. 2010 Aug 12;67(3):422-34. doi: 10.1016/j.neuron.2010.07.018. PMID: 20696380
SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells.
Smith-Hicks C, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF, Linden DJ. Nat Neurosci. 2010 Sep;13(9):1082-9. doi: 10.1038/nn.2611. Epub 2010 Aug 8. PMID: 20694003
A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal.
Merte J, Wang Q, Vander Kooi CW, Sarsfield S, Leahy DJ, Kolodkin AL, Ginty DD. J Neurosci. 2010 Apr 21;30(16):5767-75. doi: 10.1523/JNEUROSCI.5061-09.2010. PMID: 20410128
2009
Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling.
Luo W, Enomoto H, Rice FL, Milbrandt J, Ginty DD. Neuron. 2009 Dec 24;64(6):841-56. doi: 10.1016/j.neuron.2009.11.003. PMID: 20064391
Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS.
Tran TS, Rubio ME, Clem RL, Johnson D, Case L, Tessier-Lavigne M, Huganir RL, Ginty DD, Kolodkin AL. Nature. 2009 Dec 24;462(7276):1065-9. doi: 10.1038/nature08628. Epub 2009 Dec 13. PMID: 20010807
Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.
Merte J, Jensen D, Wright K, Sarsfield S, Wang Y, Schekman R, Ginty DD. Nat Cell Biol. 2010 Jan;12(1):41-6; sup pp 1-8. doi: 10.1038/ncb2002. Epub 2009 Dec 6. PMID: 19966784
Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.
Kolk SM, Gunput RA, Tran TS, van den Heuvel DM, Prasad AA, Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JP, Smidt MP, Pasterkamp RJ. J Neurosci. 2009 Oct 7;29(40):12542-57. doi: 10.1523/JNEUROSCI.2521-09.2009. PMID: 19812329
LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.
Mandai K, Guo T, St Hillaire C, Meabon JS, Kanning KC, Bothwell M, Ginty DD. Neuron. 2009 Sep 10;63(5):614-27. doi: 10.1016/j.neuron.2009.07.031. PMID: 19755105
2008
Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development.
Newbern J, Zhong J, Wickramasinghe RS, Li X, Wu Y, Samuels I, Cherosky N, Karlo JC, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman YQ, Charron J, Ginty DD, Watanabe M, Saitta SC, Snider WD, Landreth GE. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17115-20. doi: 10.1073/pnas.0805239105. Epub 2008 Oct 24. PMID: 18952847
The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value.
Johnson AW, Chen X, Crombag HS, Zhang C, Smith DR, Shokat KM, Gallagher M, Holland PC, Ginty DD. Eur J Neurosci. 2008 Sep;28(5):997-1002. doi: 10.1111/j.1460-9568.2008.06383.x. Epub 2008 Jul 26. PMID: 18671735
Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons.
Wickramasinghe SR, Alvania RS, Ramanan N, Wood JN, Mandai K, Ginty DD. Neuron. 2008 May 22;58(4):532-45. doi: 10.1016/j.neuron.2008.03.006. PMID: 18498735
Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons.
Makita T, Sucov HM, Gariepy CE, Yanagisawa M, Ginty DD. Nature. 2008 Apr 10;452(7188):759-63. doi: 10.1038/nature06859. PMID: 18401410
A model for neuronal competition during development.
Deppmann CD, Mihalas S, Sharma N, Lonze BE, Niebur E, Ginty DD. Science. 2008 Apr 18;320(5874):369-73. doi: 10.1126/science.1152677. Epub 2008 Mar 6. PMID: 18323418
2007
A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons.
Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty DD. Neuron. 2007 Jun 7;54(5):739-54. PMID: 17553423
2006
Retrograde control of neural circuit formation.
Deppmann CD, Ginty DD. Cell. 2006 Dec 29;127(7):1306-7. PMID: 17190596
Calcium signals control Wnt-dependent dendrite growth.
Alvania RS, Chen X, Ginty DD. Neuron. 2006 Jun 15;50(6):813-5. Review. PMID: 16772162
A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons.
Riccio A, Alvania RS, Lonze BE, Ramanan N, Kim T, Huang Y, Dawson TM, Snyder SH, Ginty DD. Mol Cell. 2006 Jan 20;21(2):283-94. PMID: 16427017
2005
Distinct roles for secreted semaphorin signaling in spinal motor axon guidance.
Huber AB, Kania A, Tran TS, Gu C, De Marco Garcia N, Lieberam I, Johnson D, Jessell TM, Ginty DD, Kolodkin AL. Neuron. 2005 Dec 22;48(6):949-64. PMID: 16364899
Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival.
Lee J, Kim CH, Simon DK, Aminova LR, Andreyev AY, Kushnareva YE, Murphy AN, Lonze BE, Kim KS, Ginty DD, Ferrante RJ, Ryu H, Ratan RR. J Biol Chem. 2005 Dec 9;280(49):40398-401. Epub 2005 Oct 5. PMID: 16207717
Functions and mechanisms of retrograde neurotrophin signalling.
Zweifel LS, Kuruvilla R, Ginty DD. Nat Rev Neurosci. 2005 Aug;6(8):615-25. Review. PMID: 16062170
Growth and survival signals controlling sympathetic nervous system development.
Glebova NO, Ginty DD. Annu Rev Neurosci. 2005;28:191-222. Review. PMID: 16022594
Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors.
Valdez G, Akmentin W, Philippidou P, Kuruvilla R, Ginty DD, Halegoua S. J Neurosci. 2005 May 25;25(21):5236-47. PMID: 15917464
SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability.
Ramanan N, Shen Y, Sarsfield S, Lemberger T, Schütz G, Linden DJ, Ginty DD. Nat Neurosci. 2005 Jun;8(6):759-67. Epub 2005 May 8. PMID: 15880109
A chemical-genetic approach to studying neurotrophin signaling.
Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD. Neuron. 2005 Apr 7;46(1):13-21. PMID: 15820690
Secreted semaphorins modulate synaptic transmission in the adult hippocampus.
Sahay A, Kim CH, Sepkuty JP, Cho E, Huganir RL, Ginty DD, Kolodkin AL. J Neurosci. 2005 Apr 6;25(14):3613-20. PMID: 15814792
2004
Restricted inactivation of serum response factor to the cardiovascular system.
Miano JM, Ramanan N, Georger MA, de Mesy Bentley KL, Emerson RL, Balza RO Jr, Xiao Q, Weiler H, Ginty DD, Misra RP. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17132-7. Epub 2004 Nov 29. PMID: 15569937
Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins.
Chen AE, Ginty DD, Fan CM. Nature. 2005 Jan 20;433(7023):317-22. Epub 2004 Nov 28. PMID: 15568017
Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins.
Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD. Science. 2005 Jan 14;307(5707):265-8. Epub 2004 Nov 18. PMID: 15550623
Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve.
Schwarz Q, Gu C, Fujisawa H, Sabelko K, Gertsenstein M, Nagy A, Taniguchi M, Kolodkin AL, Ginty DD, Shima DT, Ruhrberg C. Genes Dev. 2004 Nov 15;18(22):2822-34. PMID: 15545635
Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections.
Cloutier JF, Sahay A, Chang EC, Tessier-Lavigne M, Dulac C, Kolodkin AL, Ginty DD. J Neurosci. 2004 Oct 13;24(41):9087-96. PMID: 15483127
A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling.
Kuruvilla R, Zweifel LS, Glebova NO, Lonze BE, Valdez G, Ye H,Ginty DD. Cell. 2004 Jul 23;118(2):243-55. PMID: 15260993
Heterogeneous requirement of NGF for sympathetic target innervation in vivo.
Glebova NO, Ginty DD. J Neurosci. 2004 Jan 21;24(3):743-51. PMID: 14736860
2003
Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events.
Sahay A, Molliver ME, Ginty DD, Kolodkin AL. J Neurosci. 2003 Jul 30;23(17):6671-8. PMID: 12890759
Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development.
Gu C, Rodriguez ER, Reimert DV, Shu T, Fritzsch B, Richards LJ, Kolodkin AL, Ginty DD. Dev Cell. 2003 Jul;5(1):45-57. PMID: 12852851
Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons.
Ye H, Kuruvilla R, Zweifel LS, Ginty DD. Neuron. 2003 Jul 3;39(1):57-68. PMID: 12848932
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF. Annu Rev Neurosci. 2003;26:509-63. Epub 2003 Mar 28. Review. PMID: 12677003
2002
Function and regulation of CREB family transcription factors in the nervous system.
Lonze BE, Ginty DD. Neuron. 2002 Aug 15;35(4):605-23. Review. PMID: 12194863
Retrograde neurotrophin signaling: Trk-ing along the axon.
Ginty DD, Segal RA. Curr Opin Neurobiol. 2002 Jun;12(3):268-74. Review. PMID: 12049932
Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB.
Lonze BE, Riccio A, Cohen S, Ginty DD. Neuron. 2002 Apr 25;34(3):371-85. PMID: 11988169
CREB family transcription factors inhibit neuronal suicide.
Dawson TM, Ginty DD. Nat Med. 2002 May;8(5):450-1. PMID: 11984583
What a privilege to reside at the synapse: NMDA receptor signaling to CREB.
Riccio A, Ginty DD. Nat Neurosci. 2002 May;5(5):389-90. PMID: 11976696
Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons.
Cloutier JF, Giger RJ, Koentges G, Dulac C, Kolodkin AL, Ginty DD. Neuron. 2002 Mar 14;33(6):877-92. PMID: 11906695
Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165.
Gu C, Limberg BJ, Whitaker GB, Perman B, Leahy DJ, Rosenbaum JS, Ginty DD, Kolodkin AL. J Biol Chem. 2002 May 17;277(20):18069-76. Epub 2002 Mar 8. PMID: 11886873
2001
SH2-B and APS are multimeric adapters that augment TrkA signaling.
Qian X, Ginty DD. Mol Cell Biol. 2001 Mar;21(5):1613-20. PMID: 11238898
2000
Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons.
Kuruvilla R, Ye H, Ginty DD. Neuron. 2000 Sep;27(3):499-512. PMID: 11055433
Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism.
Sasaki M, Gonzalez-Zulueta M, Huang H, Herring WJ, Ahn S,Ginty DD, Dawson VL, Dawson TM. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8617-22. PMID: 10900019
Spatial considerations for stimulus-dependent transcription in neurons.
Ahn S, Riccio A, Ginty DD. Annu Rev Physiol. 2000;62:803-23. Review. PMID: 10845112
Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins.
Giger RJ, Cloutier JF, Sahay A, Prinjha RK, Levengood DV, Moore SE, Pickering S, Simmons D, Rastan S, Walsh FS, Kolodkin AL, Ginty DD, Geppert M. Neuron. 2000 Jan;25(1):29-41. PMID: 10707970
1999
Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons.
Riccio A, Ahn S, Davenport CM, Blendy JA, Ginty DD. Science. 1999 Dec 17;286(5448):2358-61. PMID: 10600750
Characterization of an NGF-P-TrkA retrograde-signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons.
Tsui-Pierchala BA, Ginty DD. J Neurosci. 1999 Oct 1;19(19):8207-18. PMID: 10493722
A late phase of cerebellar long-term depression requires activation of CaMKIV and CREB.
Ahn S, Ginty DD, Linden DJ. Neuron. 1999 Jul;23(3):559-68. PMID: 10433267
1998
Patterning of cortical efferent projections by semaphorin-neuropilin interactions.
Polleux F, Giger RJ, Ginty DD, Kolodkin AL, Ghosh A. Science. 1998 Dec 4;282(5395):1904-6. PMID: 9836643
Effects of PS1 deficiency on membrane protein trafficking in neurons.
Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Neuron. 1998 Nov;21(5):1213-21. PMID: 9856475
Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity.
Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL. Neuron. 1998 Nov;21(5):1079-92. PMID: 9856463
Identification and characterization of novel substrates of Trk receptors in developing neurons.
Qian X, Riccio A, Zhang Y, Ginty DD. Neuron. 1998 Nov;21(5):1017-29. PMID: 9856458
A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos.
Ahn S, Olive M, Aggarwal S, Krylov D, Ginty DD, Vinson C. Mol Cell Biol. 1998 Feb;18(2):967-77. PMID: 9447994
1997
Steering clear of semaphorins: neuropilins sound the retreat.
Kolodkin AL, Ginty DD. Neuron. 1997 Dec;19(6):1159-62. Review. PMID: 9427240
Neuropilin is a semaphorin III receptor.
Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD. Cell. 1997 Aug 22;90(4):753-62. PMID: 9288754
An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons.
Riccio A, Pierchala BA, Ciarallo CL, Ginty DD. Science. 1997 Aug 22;277(5329):1097-100. PMID: 9262478
Calcium regulation of gene expression: isn't that spatial?
Ginty DD. Neuron. 1997 Feb;18(2):183-6. Review. PMID: 9052789
1996
Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.
Xing J, Ginty DD, Greenberg ME. Science. 1996 Aug 16;273(5277):959-63. PMID: 8688081
Light entrainment and activation of signal transduction pathways in the SCN.
Kornhauser JM, Ginty DD, Greenberg ME, Mayo KE, Takahashi JS. Prog Brain Res. 1996;111:133-46. Review. PMID: 8990912
1995
Induction of a nerve growth factor-sensitive kinase that phosphorylates the DNA-binding domain of the orphan nuclear receptor NGFI-B.
Hirata Y, Whalin M, Ginty DD, Xing J, Greenberg ME, Milbrandt J, Guroff G. J Neurochem. 1995 Oct;65(4):1780-8. PMID: 7561876
Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase.
Miranti CK, Ginty DD, Huang G, Chatila T, Greenberg ME. Mol Cell Biol. 1995 Jul;15(7):3672-84. PMID: 7791774
Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals.
Bonni A, Ginty DD, Dudek H, Greenberg ME. Mol Cell Neurosci. 1995 Apr;6(2):168-83. PMID: 7551568
L-type voltage-sensitive Ca2+ channel activation regulates c-fos transcription at multiple levels.
Thompson MA, Ginty DD, Bonni A, Greenberg ME. J Biol Chem. 1995 Mar 3;270(9):4224-35. PMID: 7876182
Calcium regulation of gene expression.
Rosen LB, Ginty DD, Greenberg ME. Adv Second Messenger Phosphoprotein Res. 1995;30:225-53. Review. PMID: 7695991
1994
Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.
Ginty DD, Bonni A, Greenberg ME. Cell. 1994 Jun 3;77(5):713-25. PMID: 8205620
Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras.
Rosen LB, Ginty DD, Weber MJ, Greenberg ME. Neuron. 1994 Jun;12(6):1207-21. PMID: 8011335
Calcium regulation of gene expression in neuronal cells.
Ghosh A, Ginty DD, Bading H, Greenberg ME. J Neurobiol. 1994 Mar;25(3):294-303. Review. PMID: 7910846
1993
A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.
Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME. Mol Cell Biol. 1993 Oct;13(10):6260-73. PMID: 8413226
Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.
Ginty DD, Kornhauser JM, Thompson MA, Bading H, Mayo KE, Takahashi JS, Greenberg ME. Science. 1993 Apr 9;260(5105):238-4. PMID: 8097062
Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.
Bading H, Ginty DD, Greenberg ME. Science. 1993 Apr 9;260(5105):181-6. PMID: 8097060
1992
Trans-synaptic regulation of gene expression.
Ginty DD, Bading H, Greenberg ME. Curr Opin Neurobiol. 1992 Jun;2(3):312-6. Review. PMID: 1322751
The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells.
Ginty DD, Fanger GR, Wagner JA, Maue RA. J Cell Biol. 1992 Mar;116(6):1465-73. PMID: 1311713
Synergistic effects of nerve growth factor and phorbol 12-myristate 13-acetate on rapid motility and process formation in PC12 cells: the role of laminin.
Glowacka D, Ginty DD, Wagner JA. J Neurosci Res. 1992 Feb;31(2):263-72. PMID: 1573676
1991
Induction of immediate early genes by Ca2+ influx requires cAMP-dependent protein kinase in PC12 cells.
Ginty DD, Glowacka D, Bader DS, Hidaka H, Wagner JA. J Biol Chem. 1991 Sep 15;266(26):17454-8. PMID: 1910045
Nerve growth factor-induced neuronal differentiation after dominant repression of both type I and type II cAMP-dependent protein kinase activities.
Ginty DD, Glowacka D, DeFranco C, Wagner JA. J Biol Chem. 1991 Aug 15;266(23):15325-33. PMID: 1651325
Retinoic acid stimulates the differentiation of PC12 cells that are deficient in cAMP-dependent protein kinase.
Scheibe RJ, Ginty DD, Wagner JA. J Cell Biol. 1991 Jun;113(5):1173-82. PMID: 1645738
1990
Multiple pathways for the regulation of ornithine decarboxylase in intestinal epithelial cells.
Ginty DD, Marlowe M, Pekala PH, Seidel ER. Am J Physiol. 1990 Mar;258(3 Pt 1):G454-60. PMID: 2107756
Apparent post-transcriptional modification of ornithine decarboxylase accounts for its induction in IEC-6 cells in culture.
Seidel ER, Ginty DD. Digestion. 1990;46 Suppl 2:383-9. PMID: 2262070
1989
Putrescine stimulates DNA synthesis in intestinal epithelial cells.
Ginty DD, Osborne DL, Seidel ER. Am J Physiol. 1989 Jul;257(1 Pt 1):G145-50. PMID: 2473652
Polyamine-dependent growth and calmodulin-regulated induction of ornithine decarboxylase.
Ginty DD, Seidel ER. Am J Physiol. 1989 Feb;256(2 Pt 1):G342-8. PMID: 2493197
1987
Neurogenic pulmonary edema in a pulmonary normotensive model.
Beckman DL, Ginty DD, Gaither AC. Proc Soc Exp Biol Med. 1987 Nov;186(2):170-3. PMID: 3671355
A pyrene fluorescence technique and microchamber for measurement of oxygen consumption of single isolated axons.
Hargittai PT, Ginty DD, Lieberman EM. Anal Biochem. 1987 Jun;163(2):418-26. PMID: 3661989
